Dr. Grimes has helped to introduce evidence-based medicine
to American obstetrics and gynecology. His research interests bridge the disciplines of clinical obstetrics and
gynecology and public health. His research over the past four decades has focused on fertility regulation, including
contraception, abortion, and sterilization. He has also contributed to the literature on sexually transmitted diseases
and technology assessment.
An expert in clinical
research, he has published numerous articles on research methods; these include series on clinical research published in The
Lancet in 2002 and in 2005. This led to the publication in 2006 of The Lancet Handbook of
Essential Concepts in Clinical Research.
of his expertise in evidence-based medicine, he served on the U.S. Preventive Services Task Force, and he has published
numerous Cochrane systematic reviews of fertility regulation methods.